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Rotate & Combine Crops & Controls | Prevent Resistance Buildup in Pests & Pathogens

Slow pesticide resistance by rotating crops and controls, combining products with different modes of action, and using resistance-proof options.
By Hensley’s Seed Co.
Rotate Crops & Controls to Prevent Resistance in Pests & Pathogens

Preventing Resistance Buildup in Pests & Pathogens

Alternating Crops & Controls

Here are some examples of rotating controls, combining them, and choosing controls pests can't become resistant to, all ways to slow resistance in pests and diseases.


When the same crop or crop family goes into the same ground year after year, its pests and diseases tend to build up and can become resistant to the controls used against them.

Crop rotation is one of the best ways to stop crop-specific pathogens from building up in the soil and growing area, and to cut down on pests that overwinter there. Rotating crop families is best, but switching crops within a family, or varieties within a crop, also helps. Varieties respond differently to disease and pests, so when you know you have a particular disease, choose resistant varieties. Changing varieties also makes it harder for a pathogen to adapt.

When crop and variety rotation aren't enough, alternating your controls also slows resistance, and some controls work better together. That means either spraying different products in turn or mixing compatible products in one tank.

Rotating Controls for Early & Late Blight

Rotate Controls for Early & Late Blight
Alternating controls to prevent blight.

In our trial plots, to prevent early and late blight on tomatoes, we usually start with OxiDate® (a hydrogen peroxide–based fungicide and bactericide) to clean up the plants, then follow with a copper fungicide.

At the next spray we might use OxiDate again and follow it with a different product, such as Actinovate®.

Combining controls for European corn borer and cucumber beetles
Controls can be combined for treating European Corn Borer or Cucumber Beetles
Tank mixing can help against European corn borer and cucumber beetles.

Mixing products with different modes of action slows resistance because each attacks a different target. Against European corn borer, for example, spinosad, the active ingredient in Monteray Garden Insect Spray, acts on the insect's nervous system, while Bacillus thuringiensis, the active ingredient in DiPel® DF, attacks the gut. A tank mix of products like these can work better than either one alone.

Likewise, against cucumber beetles, PyGanic® (a pyrethrin insecticide) can be mixed with Surround® WP (a kaolin clay repellent) for a quick knockdown followed by ongoing repellency.

Using Resistance-Proof Controls

Environmentally Conscious, Resistance-Proof Pest Control
Some controls are both gentle on the environment and very hard for pests to resist.

Pests generally can't develop resistance to certain physical controls. Diatomaceous earth is made of fossilized diatoms whose sharp edges damage insects' outer layer, killing them by drying them out after contact or ingestion, usually within a couple of days. Highly refined paraffinic oils smother the eggs, larvae, nymphs and adults of soft-bodied insects and mites, and other horticultural oils and insecticidal soaps also control pests with little risk of resistance.

Sluggo® is a granular bait based on iron phosphate, a naturally occurring mineral that breaks down into plant nutrients, mixed with bait that draws in slugs and snails. Iron phosphate baits are considered low in toxicity to people, pets and wildlife when used as directed, and slugs and snails don't become resistant to them.

Take Notes, Mix It Up & Keep It Safe

These are only a few of the ways to get the control you need while limiting resistance. Whether you farm commercially or garden at home, keep good records of which pests and diseases show up, what you used and how well it worked. Always read and follow the label exactly when applying any control. Used sensibly, crop rotation, control rotation, combining controls and resistance-proof options are safe, effective and good for the environment.

Learn More

Resistance vs. Tolerance
Pesticide resistance means a pest population targeted by a pesticide has adapted and become less susceptible to it.

The Insecticide Resistance Action Committee (IRAC), defines resistance as "a heritable change in the sensitivity of a pest population that is reflected in the repeated failure of a product to achieve the expected level of control when used according to the label recommendation for that pest species."

Pesticide tolerance has a different meaning: the legal limit for pesticide residue that may remain in or on a harvested crop.

Resistance and tolerance are different things , although people argue about the terms and often mix them up.

Even low-level resistance is resistance, not tolerance.

When an entire species naturally survives a particular product, that is tolerance, not resistance. Aphids, for example, aren't killed by the insecticide carbaryl (Sevin). They didn't evolve resistance from repeated spraying; they have simply always tolerated it.

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